Indole-3-lactic acid associated with Bifidobacterium-dominated microbiota significantly decreases inflammation in intestinal epithelial cells.
Amy M EhrlichAlline R PachecoBethany M HenrickDiana TaftGege XuM Nazmul HudaDarya MishchukMichael L GoodsonCarolyn SlupskyDaniela BarileCarlito B LebrillaCharles B StephensenDavid A MillsHelen E RaybouldPublished in: BMC microbiology (2020)
These findings suggest that ILA, a predominant metabolite from B. infantis grown on HMO and elevated in infant stool high in B. infantis, and protects gut epithelial cells in culture via activation of the AhR and Nrf2 pathway.
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