[Expression of immune checkpoints PD-L1, CTLA4, LAG3 in the microenvironment of colon adenocarcinoma depending on MMR status].

Sergei Sergeevich Naumov N V Krakhmal Liubov Alexandrovna Tashireva Sergey V Vtorushin

Published in: Arkhiv patologii (2024)

A study using multiplex immunohistochemical analysis showed that MMR-deficient colon adenocarcinomas are characterized by more pronounced immune infiltration and increased expression of immune checkpoints in microenvironmental cells, mainly in the area of invasive tumor growth. The data obtained may be important for understanding the mechanisms of immune-mediated control of tumor growth and the choice of immunotherapy tactics depending on MMR status.

Keyphrases

poor prognosis
squamous cell carcinoma
stem cells
binding protein
electronic health record
long non coding rna
big data
radiation therapy
locally advanced
artificial intelligence
deep learning
rectal cancer
data analysis
single cell