Impact of antipsychotics in children and adolescents with autism spectrum disorder: a systematic review and meta-analysis.

Gian Loreto D'AlòFranco De CrescenzoLaura AmatoFabio CrucianiMarina DavoliFrancesca FulceriSilvia MinozziZuzana MitrovaGian Paolo MorganoFranco NardocciRosella SaulleHolger Jens SchünemannMaria Luisa Scattoninull null

Published in: Health and quality of life outcomes (2021)

Our systematic review and meta-analysis found antipsychotics for children and adolescents with ASD more efficacious than placebo in reducing stereotypies, hyperactivity, irritability and obsessions, compulsions, and in increasing social communication and global functioning. Antipsychotics were also found to be more acceptable, but less safe than placebo.

Keyphrases

autism spectrum disorder
double blind
healthcare
phase iii
attention deficit hyperactivity disorder
randomized controlled trial
open label