Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine Receptors.
Suzzane HoraniEvan P StaterPierre-Jean CorringerJames R TrudellR Adron HarrisRebecca J HowardPublished in: Alcoholism, clinical and experimental research (2015)
Our results are consistent with a TM mechanism of EtOH modulation in Cys-loop receptors. This work highlights the relevance of bacterial homologs as valuable model systems for studying ion channel function of human receptors and demonstrates the modularity of these channels across species.