IL1RAP expression and the enrichment of IL-33 activation signatures in severe neutrophilic asthma.

Yusef Eamon BadiBarbora SalcmanAdam TaylorBatika RanaNazanin Zounemat KermaniJohn H RileySally WorsleySharon MumbySven-Eric DahlenDavid CousinsSilvia Bulfone-PausKaren AffleckKian Fan ChungStewart BatesIssssswan M Adcock

Published in: Allergy (2022)

IL-33-activated gene signatures are elevated in neutrophilic and mixed granulocytic asthma corresponding with IL1RAP co-receptor expression. This suggests incorporating T2-low asthma in anti-IL-33 trials.

Keyphrases

chronic obstructive pulmonary disease
lung function
genome wide
poor prognosis
allergic rhinitis
gene expression
long non coding rna
transcription factor
drug induced