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Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles Elicit Better Preservation of the Intra-Renal Microvasculature Than Renal Revascularization in Pigs with Renovascular Disease.

Christopher M FergusonRahele A FarahaniXiang-Yang ZhuHui TangKyra L JordanIshran M SaadiqAmir LermanLilach Orly LermanAlfonso Eirin
Published in: Cells (2021)
MSC-derived EVs elicit a better preservation of the stenotic kidney microvasculature and greater attenuation of renal injury and fibrosis compared to PTRA, possibly partly attributed to their cargo of vasculo-protective genes. Yet, both strategies similarly improve renal hemodynamics and function. These observations shed light on diverse mechanisms implicated in improvement of post-stenotic kidney function and position EVs as a promising therapeutic intervention in RVD.
Keyphrases
  • bone marrow
  • randomized controlled trial
  • stem cells
  • percutaneous coronary intervention
  • coronary artery bypass grafting
  • atrial fibrillation