Longitudinal impact of dapagliflozin treatment on ventricular repolarization heterogeneity in patients with type 2 diabetes.

Tatsuya SatoTakayuki MikiShinya FurukawaBunzo MatsuuraYoichi HiasaHirofumi OhnishiMasaya TannoTetsuji Miura

Published in: Journal of diabetes investigation (2019)

QTc dispersion (QTcd) tended to be decreased at 24 weeks and was significantly decreased at 2 years after dapagliflozin treatment. In the subgroup with QTcd?53.7 ms (median), QTcd was significantly decreased at 24 weeks and remained improved for 2 years. Dapagliflozin also significantly reduced Tpeak-Tend/QT in a subgroup with Tpeak-Tend/QT?0.25 (median).

Keyphrases

heart failure
mass spectrometry
ms ms
cross sectional
gestational age
phase iii
study protocol
open label
smoking cessation