In Sjögren's Syndrome (SS), clinical heterogeneity and discordance between disease activity measures and patient experience are key obstacles to effective therapeutic development. Patient reported outcome measures (PROMs) are useful tools for understanding the unmet needs from the patients' perspective and therefore they are key for the development of patient centric healthcare systems. Initial concern about the subjectivity of PROMs has given way to methodological rigour and clear guidance for the development of PROMs. To date, several studies of patient stratification using PROMs have identified similar symptom-based subgroups. There is evidence to suggest that these subgroups may represent different disease endotypes with differing responses to therapeutic interventions. Stratified medicine approaches, alongside sensitive outcome measures, have the potential to improve our understanding of SS pathobiology and therapeutic development. The inclusion of PROMs is important for the success of such approaches. In this review we discuss the opportunities of using PROMs in understanding the pathogenesis of and therapeutic development for SS.
Keyphrases
- patient reported outcomes
- disease activity
- patient reported
- healthcare
- end stage renal disease
- systemic lupus erythematosus
- rheumatoid arthritis
- case report
- chronic kidney disease
- ejection fraction
- newly diagnosed
- peritoneal dialysis
- risk assessment
- physical activity
- ankylosing spondylitis
- rheumatoid arthritis patients
- single cell