Urea Hydrogen Peroxide and Ethyl Lactate, an Eco-Friendly Combo System in the Direct C(sp 2 )-H Bond Selenylation of Imidazo[2,1- b ]thiazole and Related Structures.
Cassio Augusto de Oliveira MoraesRafaely B C SantosMarcos F O CavalcanteJhefferson S GuilhermiMuhammad A AliGiancarlo V BotteselleTiago E A FrizonMuhammad Ishaq Ali ShahLuciano Morais LiãoAdilson BeatrizSumbal SabaJamal RafiquePublished in: ACS omega (2023)
Herein, we describe a urea hydrogen peroxide-mediated sustainable protocol for the synthesis of selenylated imidazo[2,1- b ]thiazole by using half molar equivalent diorganyl diselenides in ethyl lactate as a greener solvent. The reaction features high yields, easy performance on gram scale, metal-free conditions, as well as applicability to imidazopyridine and imidazopyrimidine.