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Toll-like receptor 2, hyaluronan, and neutrophils play a key role in plaque erosion: the OPTICO-ACS study.

Denitsa MetevaRamona VinciClaudio SeppeltYoussef S AbdelwahedDaniela PedicinoGregor NellesCarsten SkurkArash HaghikiaUrsula Rauch-KröhnertTeresa GerhardtElisabeth StraesslerYingjie ZhaoFelix GollaMichael JonerHimanshu RaiAdelheid KratzerHector Giral ArnalGiovanna LiuzzoJens KlotscheFilippo CreaUlf LandmesserDavid M LeistnerNicolle Kränkel
Published in: European heart journal (2023)
The current study provides first in-human evidence for distinct TLR2-mediated neutrophil activation in IFC-ACS, presumably triggered by elevated soluble hyaluronic acid. Together with disturbed flow conditions, neutrophil-released MMP9 might be promoting endothelial cell loss-triggered thrombosis and therefore providing a potential future target for a phenotype-specific secondary therapeutic approach in IFC-ACS.
Keyphrases
  • toll like receptor
  • acute coronary syndrome
  • endothelial cells
  • hyaluronic acid
  • inflammatory response
  • immune response
  • nuclear factor
  • climate change
  • current status
  • human health
  • pluripotent stem cells