β-catenin mediates endodermal commitment of human ES cells via distinct transactivation functions.

Xun MaLiujiang DaiChunlai TanJiangchuan LiXiangjun HeYaofeng WangJunyi XueMin HuangJianwei RenYin XiaQiang WuHui ZhaoWai-Yee ChanBo Feng

Published in: Cell & bioscience (2024)

Our study uncovered an unconventional regulatory function of β-catenin through weak transactivation, indicating that the levels of β-catenin activity determine the lineage bifurcation from mesendoderm into endoderm and mesoderm.

Keyphrases

epithelial mesenchymal transition
cell proliferation
induced apoptosis
pluripotent stem cells
endothelial cells
cell cycle arrest
transcription factor
signaling pathway
cell death
oxidative stress
cell fate
pi k akt