The Role of MAP3K1 in the Development of the Female Reproductive Tract.

Eiki KimuraMaureen MonganBo XiaoJingjing WangVinicius S Carreira Brad BolonXiang ZhangKatherine A Burns Jacek Biesiada Mario Medvedovic Alvaro Puga Ying Xia

Published in: bioRxiv : the preprint server for biology (2023)

MAP3K1 deficient female mice exhibit imperforate vagina and infertilityLoss of MAP3K1 kinase activity impedes Müllerian duct (MD) caudal elongation and fusion with urogenital sinus (UGS) in embryogenesisThe MAP3K1-MAPK pathway up-regulates WNT signaling in epithelial cellsMAP3K1 deficiency down-regulates Wnt7b expression in the MD epithelium and prevents WNT activity in mesenchyme of the caudal MD.

Keyphrases

molecular dynamics
high density
stem cells
poor prognosis
cell proliferation
signaling pathway
type diabetes
high fat diet induced
skeletal muscle
binding protein
protein kinase
wild type