Protective Effect of Borassus flabellifer Haustorium Extract against Alkoxyl Radical-Induced Cytotoxicity by Improving Glutathione Metabolism by Modulating Nrf2/Haeme Oxygenase-1 Expression.

Joice Tom JobRajakrishnan RajagopalAhmed AlfarhanYoung Ock KimHak-Jae KimArunaksharan Narayanankutty

Published in: Journal of the American College of Nutrition (2021)

The study indicated the potential of methanolic extract of Borassus flabellifer haustorium in enhancing the de novo glutathione biosynthesis in normal and pro-oxidant exposed cells by Nrf2/HO1 dependent manner, concomitantly mitigating the toxicity of AAPH-derived alkoxyl radicals in intestinal epithelial cells.

Keyphrases

oxidative stress
induced apoptosis
diabetic rats
anti inflammatory
poor prognosis
cell cycle arrest
high glucose
signaling pathway
pi k akt
endoplasmic reticulum stress
cell death
long non coding rna
human health
cell proliferation
risk assessment