Yes-associated protein (YAP) induces a secretome phenotype and transcriptionally regulates plasminogen activator Inhibitor-1 (PAI-1) expression in hepatocarcinogenesis.
Simone MarquardStefan ThomannSofia M E WeilerMichaela BissingerTeresa LutzCarsten StichtMarcell TóthCarolina de la TorreNorbert GretzBeate K StraubJens MarquardtPeter SchirmacherKai BreuhahnPublished in: Cell communication and signaling : CCS (2020)
These results demonstrate that the oncogene YAP changes the secretome response of hepatocytes and hepatocyte-derived tumor cells. In this context, the secreted protein PAI-1 is transcriptionally regulated by YAP in hepatocarcinogenesis. Perturbation of these YAP-dependent communication hubs including PAI-1 may represent a promising pharmacological approach in tumors with YAP overexpression. Video abstract.