Harnessing the Power of Stimuli-Responsive Nanoparticles as an Effective Therapeutic Drug Delivery System.
Mahak FatimaWaleed H AlmalkiTasneem KhanAmirhossein SahebkarPrashant KesharwaniPublished in: Advanced materials (Deerfield Beach, Fla.) (2024)
The quest for effective and reliable methods of delivering medications, with the aim of improving delivery of therapeutic agent to the intended location, has presented a demanding yet captivating field in biomedical research. The concept of smart drug delivery systems is an evolving therapeutic approach, serving as a model for directing drugs to specific targets or sites. These systems have been developed to specifically target and regulate the administration of therapeutic substances in a diverse array of chronic conditions, including periodontitis, diabetes, cardiac diseases, inflammatory bowel diseases, rheumatoid arthritis, and different cancers. Nevertheless, numerous comprehensive clinical trials are still required to ascertain both the immediate and enduring impacts of such nanosystems on human subjects. This review delves into the benefits of different drug delivery vehicles, aiming to enhance comprehension of their applicability in addressing present medical requirements. Additionally, it touches upon the current applications of these stimuli-reactive nanosystems in biomedicine and outlines future development prospects.
Keyphrases
- rheumatoid arthritis
- drug delivery
- clinical trial
- endothelial cells
- healthcare
- cardiovascular disease
- type diabetes
- current status
- cancer therapy
- high throughput
- randomized controlled trial
- systemic lupus erythematosus
- big data
- heart failure
- metabolic syndrome
- young adults
- machine learning
- single cell
- phase ii
- atrial fibrillation
- idiopathic pulmonary fibrosis
- phase iii
- drug release