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A phase I open-label study of the safety and efficacy of apatinib (rivoceranib) administered to patients with advanced malignancies to improve sensitivity to pembrolizumab in the second- or later-line setting (APPEASE).

Matthew GumbletonStephanie AllanHannah ConwayKenneth M BoucherJames MarvinJosiah HawksWilliam BurnettMatthew Van BrocklinJonathan WhisenantGlynn GilcreaseSumati V Gupta
Published in: BMC research notes (2023)
Clinical trial registration number: NCT03407976. Date of registration: January 17, 2018.
Keyphrases
  • clinical trial
  • open label
  • phase ii
  • study protocol
  • phase ii study
  • randomized controlled trial
  • advanced non small cell lung cancer
  • double blind
  • rectal cancer