Hepatocyte growth factor alleviates hepatic insulin resistance and lipid accumulation in high-fat diet-fed mice.

Yali JingQingmin SunXiaolu XiongRan MengSunyinyan TangShu CaoYan Bi Dalong Zhu

Published in: Journal of diabetes investigation (2018)

HGF treatment can ameliorate hepatic insulin resistance and steatosis through regulation of lipid metabolism. These effects might occur through farnesoid X receptor-small heterodimer partner axis-dependent transcriptional activity.

Keyphrases

insulin resistance
high fat diet
growth factor
high fat diet induced
adipose tissue
metabolic syndrome
skeletal muscle
polycystic ovary syndrome
type diabetes
gene expression
transcription factor
combination therapy
liver injury
glycemic control
fatty acid
oxidative stress
weight loss
heat shock
wild type