Pretreatment of Nicorandil Protects the Heart from Exhaustive Exercise-Induced Myocardial Injury in Rats.

Lei LvLin LiYiyong ZhuAnwar AzharYao LiYongyuan WangTao JinXin YinXi Chen Yu Liu Yong Zhong

Published in: Evidence-based complementary and alternative medicine : eCAM (2022)

Our result demonstrated that nicorandil has protective effects in EE-induced myocardial injury with dose-dependent effects. A combination of nicorandil and EP can further improve the protective effects. Taken together, nicorandil can be potentially used as an intervention method in EE-induced myocardial injury.

Keyphrases

high glucose
diabetic rats
randomized controlled trial
heart failure
drug induced
endothelial cells
oxidative stress