Central Role of Semaphorin 3B in a Serum-Induced Arthritis Model and Reduced Levels in Patients With Rheumatoid Arthritis.
Ana IgeaTiago CarvalheiroBeatriz Malvar-FernándezSara Martinez-RamosCarlos Rafael-VidalEllis NiemantsverdrietJezabel VaradéAndrea Fernández-CarreraNorman JimenezTrudy McGarryAngela Rodriguez-TrilloDouglas VealeUrsula FearonCarmen CondeJose María Pego-ReigosaÁfrica González-FernándezKris A ReedquistTimothy R D J RadstakeAnnette van der Helm-Van MilSamuel García PérezPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
Sema3B expression plays a protective role in a mouse model of arthritis. In RA patients, expression levels of Sema3B in the serum depend on the disease stage, suggesting different regulatory roles in disease onset and progression.