Rechargeable aqueous Zn-ion batteries have been deemed a promising energy storage device. However, the dendrite growth and side reactions have hindered their practical application. Herein, inspired by the ultrafluidic and K + ion-sieving flux through enzyme-gated potassium channels (KcsA) in biological plasma membranes, a metal-organic-framework (MOF-5) grafted with -ClO 4 groups (MOF-ClO 4 ) as functional enzymes is fabricated to mimic the ultrafluidic lipid-bilayer structure for gating Zn 2+ 'on' and anions 'off' states. The MOF-ClO 4 achieved perfect Zn 2+ /SO 4 2- selectivity (∼10), enhanced Zn 2+ transfer number ([Formula: see text]) and the ultrafluidic Zn 2+ flux (1.9 × 10 -3 vs. 1.67 mmol m -2 s -1 for KcsA). The symmetric cells based on MOF-ClO 4 achieve a lifespan of over 5400 h at 10 mA cm -2 /20 mAh cm -2 . Specifically, the performance of the PMCl-Zn//V 2 O 5 pouch cell keeps 81% capacity after 2000 cycles at 1 A g -1 . The regulated ion transport, by learning from a biological plasma membrane, opens a new avenue towards ultralong lifespan aqueous batteries.