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Protective Effects of CISD2 and Influence of Curcumin on CISD2 Expression in Aged Animals and Inflammatory Cell Model.

Chai-Ching LinTien-Huang ChiangYu-Yo SunMuh-Shi Lin
Published in: Nutrients (2019)
We hypothesize that the protective effects of curcumin treatment in reducing cellular inflammation associated trauma, degenerative, and aging processes can be partially attributed to elevated CISD2 expression. We observed a reduction in the protective effects of curcumin against injury-induced inflammation and mitochondrial dysfunction in cells where CISD2 expression was reduced by siCISD2.
Keyphrases
  • poor prognosis
  • oxidative stress
  • induced apoptosis
  • long non coding rna
  • single cell
  • cell death
  • cell cycle arrest
  • signaling pathway
  • endothelial cells