Genetic Context of optrA and poxtA in Florfenicol-Resistant Enterococci Isolated from Flowing Surface Water in Switzerland.

Michael Biggel Magdalena Nüesch-InderbinenChristoph JansMarc J A StevensRoger Stephan

Published in: Antimicrobial agents and chemotherapy (2021)

Linezolid is an important last-resort antibiotic for the treatment of multidrug-resistant enterococci. The aim of this study was to further characterize the genetic context of optrA and poxtA in 10 florfenicol-resistant enterococci isolated from flowing surface water. In most genomes, optrA and poxtA were embedded in transposition units integrated into plasmids or into the chromosomal radC. For the first time, a chromosomally integrated optrA in an Enterococcus raffinosus isolate is described.

Keyphrases

methicillin resistant staphylococcus aureus
multidrug resistant
copy number
genome wide
escherichia coli
klebsiella pneumoniae
staphylococcus aureus
drug resistant
acinetobacter baumannii
biofilm formation
gene expression
pseudomonas aeruginosa
cystic fibrosis