Body mass index associated with childhood and adolescent high-risk B-cell acute lymphoblastic leukemia risk: A Children's Oncology Group report.
Taumoha GhoshMichaela RichardsonPeter M GordonJustin R RyderLogan G SpectorLucie M TurcottePublished in: Cancer medicine (2020)
Pre-treatment obesity is associated with HR B-ALL among males and Hispanics, as well as with CNS involvement, suggesting common physiology between obesity and leukemogenesis. An association between underweight and ALL was confirmed, likely due to cancer-associated wasting. These results have important public health implications for obesity prevention and treatment in children and adolescents to reduce cancer risk.
Keyphrases
- insulin resistance
- public health
- metabolic syndrome
- acute lymphoblastic leukemia
- weight gain
- body mass index
- weight loss
- type diabetes
- young adults
- high fat diet induced
- mental health
- physical activity
- blood brain barrier
- adipose tissue
- acute myeloid leukemia
- skeletal muscle
- allogeneic hematopoietic stem cell transplantation
- global health
- smoking cessation