Differential Phospho-Signatures in Blood Cells Identify LRRK2 G2019S Carriers in Parkinson's Disease.

Alicia GarridoEnrique SantamaríaJoaquín Fernández-IrigoyenMarta SotoCristina SimonetManel FernándezDonina ObiangEduardo TolosaMaría-José MartíShalini PadmanabhanCristina MalageladaMario Ezquerra Rubén Fernández-Santiago

Published in: Movement disorders : official journal of the Movement Disorder Society (2022)

We found a differential phospho-signature associated with LRRK2 G2019S for which, consistent with disease status, the phospho-profile from PD at-risk G2019S L2NMCs was more similar to healthy controls than patients with G2019S L2PD with the manifested disease. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

induced apoptosis
randomized controlled trial
gene expression
systematic review
cell death