Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study.

Ashley Budu-AggreyBen BrumptonJessica Tyrrell Sarah Holmes Watkins Ellen H Modalsli Carlos A Celis-Morales Lyn D Ferguson Gunnhild Åberge Vie Tom M Palmer Lars G FritscheMari LøsetJonas Bille Nielsen Wei Zhou Lam C TsoiAndrew R WoodSamuel E Jones Robin N BeaumontMarit SaunesPål Richard Romundstad Stefan SiebertIain B McInnesJames T Elder George Davey Smith Timothy M Frayling Bjørn Olav Åsvold Sara J BrownNaveed SattarLavinia Paternoster

Published in: PLoS medicine (2019)

Our study, using genetic variants as instrumental variables for BMI, provides evidence that higher BMI leads to a higher risk of psoriasis. This supports the prioritization of therapies and lifestyle interventions aimed at controlling weight for the prevention or treatment of this common skin disease. Mechanistic studies are required to improve understanding of this relationship.

Keyphrases

body mass index
physical activity
weight gain
weight loss
metabolic syndrome
cardiovascular disease
atopic dermatitis
combination therapy