STING activation increases the efficiency of temozolomide in PTEN harbouring glioblastoma cells.

Zafer Yildirim Eda Doğan Hale Güler Kara Buket Kosova Vildan Bozok Cetintas

Published in: Turkish journal of medical sciences (2024)

Our data offers new evidence suggesting that STING agonists can effectively be used to increase temozolomide response in the presence of PTEN protein. Therefore, increased GBM therapy success rates can be achieved by employing the PTEN expression status as a predictive biomarker before treating patients with a chemotherapeutic agent in combination with STING agonist.

Keyphrases

pi k akt
cell cycle arrest
cell proliferation
induced apoptosis
signaling pathway
poor prognosis
binding protein
newly diagnosed
electronic health record
stem cells
oxidative stress
endoplasmic reticulum stress
bone marrow
amino acid
small molecule
mesenchymal stem cells
long non coding rna