Modified Ames test using a strain expressing human sulfotransferase 1C2 to assess the mutagenicity of methyleugenol.

Hiroshi HondaKazuyuki MinegawaYurika FujitaNoriko YamaguchiYoshihiro OgumaHansruedi GlattNaohiro NishiyamaToshio Kasamatsu

Published in: Genes and environment : the official journal of the Japanese Environmental Mutagen Society (2016)

We established Ames-test conditions enabling the detection of ME-induced mutagenicity, using a strain expressing human SULT1C2 in the presence of induced-rat S9 Mix. This simple approach will help assess the mutagenicity of other alkenylbenzenes and related chemicals.

Keyphrases

endothelial cells
high glucose
induced pluripotent stem cells
pluripotent stem cells
drug induced
label free
quantum dots
loop mediated isothermal amplification