Evaluating Demographic Representation in Clinical Trials: Use of the Adaptive Coronavirus Disease 2019 Treatment Trial (ACTT) as a Test Case.
Ana M Ortega-VillaNoreen A HynesCorri B LevineKatherine YangZanthia WileyNikolaus JilgJing WangJennifer A WhitakerChristopher J ColomboSeema U NayakHannah Jang KimNicole M IovineDilek InceStuart H CohenAdam J LangerJonathan M WorthamRobert L AtmarHana M El SahlyMamta K JainAneesh K MehtaCameron R WolfeCarlos A GomezTatiana BeresnevRichard A MularskiCatharine I PaulesAndre C KalilAngela R BrancheAnnie LuetkemeyerBarry S ZingmanJocelyn VoellMichael WhitakerMichelle S HarkinsRichard T DaveyRobert GrossbergSarah L GeorgeVictor TapsonWilliam R ShortVarduhi GhazaryanConstance A BensonLori E DoddDaniel A SweeneyKay M TomashekPublished in: Open forum infectious diseases (2023)
Although surveillance data of hospitalized cases may not be available early in an outbreak, they are a better comparator than US Census data and surveillance of all cases, which may not reflect the population affected and at higher risk of severe disease.