The Role of PIM Kinases in Pediatric Solid Tumors.
Janet Rae JulsonRaoud MarayatiElizabeth Ann BeierleLaura Lee StafmanPublished in: Cancers (2022)
PIM kinases have been identified as potential therapeutic targets in several malignancies. Here, we provide an in-depth review of PIM kinases, including their structure, expression, activity, regulation, and role in pediatric carcinogenesis. Also included is a brief summary of the currently available pharmaceutical agents targeting PIM kinases and existing clinical trials.