Natural Language Processing for Adjudication of Heart Failure Hospitalizations in a Multi-Center Clinical Trial.
Jonathan W CunninghamPulkit SinghChristopher ReederBrian Lee ClaggettPablo M Marti-CastelloteEmily S LauShaan KhurshidPuneet BatraSteven A LubitzMahnaz MaddahAnthony A PhilippakisAkshay S DesaiPatrick T EllinorOrly VardenyScott D SolomonJennifer E HoPublished in: medRxiv : the preprint server for health sciences (2023)
Our NLP model developed within a single healthcare system accurately identified HF events relative to the gold-standard CEC in an external multi-center clinical trial. Fine-tuning the model improved agreement and approximated human reproducibility. NLP may improve the efficiency of future multi-center clinical trials by accurately identifying clinical events at scale.