Pervasive promoter hypermethylation of silenced TERT alleles in human cancers.
David EsopiMindy Kim GrahamJacqueline A Brosnan-CashmanJennifer MeyersAjay VaghasiaAnuj GuptaBalasubramanian KumarMichael C HaffnerChristopher M HeaphyAngelo M De MarzoAlan K MeekerWilliam G NelsonSarah J WheelanSrinivasan YegnasubramanianPublished in: Cellular oncology (Dordrecht) (2020)
Our findings suggest that hypermethylation of the TERT promoter alleles signals transcriptional repression of those alleles, leading to attenuation of TERT activation in cancer cells. This type of fine tuning of TERT expression may account for the modest activation of TERT expression in most cancers.