Druggable epigenetic suppression of interferon-induced chemokine expression linked to MYCN amplification in neuroblastoma.

Johanna A SeierJulia ReinhardtKritika SarafSusanna S NgJulian P LayerDillon CorvinoKristina AlthoffFrank A GiordanoAlexander SchrammMatthias FischerMichael Hudecek

Published in: Journal for immunotherapy of cancer (2022)

Our results delineate a strategy for targeted epigenetic immunomodulation of high-risk NBs, whereby EHMT inhibitors alone or in combination with EZH2 inhibitors (in particular, MYCN-amplified NBs) could promote a T-cell-infiltrated TME via enhanced Th1-type chemokine expression.

Keyphrases

poor prognosis
dna methylation
gene expression
long non coding rna
high glucose
diabetic rats
endothelial cells
label free