Exosome-mediated delivery of super-repressor IκBα alleviates inflammation and joint damages in rheumatoid arthritis.

Hae-In LeeMin-Joo AhnJae-Kwang YooSo-Hee AhnSeon Young ParkHyangmi SeoMoon-Ju KimYu Jeong LeeHyun Hee JangSeung Cheol ShimEun Jeong WonCheolhyoung ParkChulhee ChoiTae Jong Kim

Published in: Arthritis research & therapy (2024)

Overall, these findings suggest that Exo-srIκB possesses anti-inflammatory properties in human RA cells and animal models, making it a promising therapeutic candidate for the treatment of RA.

Keyphrases

rheumatoid arthritis
disease activity
anti inflammatory
induced apoptosis
endothelial cells
ankylosing spondylitis
oxidative stress
interstitial lung disease
cell cycle arrest
systemic lupus erythematosus
induced pluripotent stem cells
pluripotent stem cells
systemic sclerosis
signaling pathway
cell death