Involving patients in drug development for Neglected Tropical Diseases (NTDs): A qualitative study exploring and incorporating preferences of patients with cutaneous leishmaniasis into Target Product Profile development.
María Del Mar CastroAstrid Christine ErberByron AranaGláucia CotaClaudia M DenkingerNicole HarrisonJulia KutyiLiliana López-CarvajalEmma PluggeJulia WalochnikPiero OlliaroPublished in: PLoS neglected tropical diseases (2024)
NTDs affect disadvantaged populations, often with little access to health systems. Engaging patients in designing adapted therapies could significantly contribute to the suitability of an intervention to a specific context and to compliance, by tailoring the product to the end-users' needs. This exploratory study identified preferences in a broad international patient spectrum. It provides methodological guidance on how patients can be meaningfully involved as stakeholders in the construction of a TPP of therapeutics for NTDs. CL is used as an exemplar, but the approach can be adapted for other NTDs.