The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9.
David C KleinSantana M LardoSarah J HainerPublished in: Cancer research communications (2024)
The bromodomain-containing protein BRD9 is essential for AML cell viability, but it is unclear whether this requirement is due to the protein's role as an epigenetic reader. We inhibited this activity and identified altered gene-distal chromatin regulation and transcription consistent with a more mature myeloid cell state.
Keyphrases
- acute myeloid leukemia
- transcription factor
- gene expression
- genome wide
- dna methylation
- protein protein
- amino acid
- allogeneic hematopoietic stem cell transplantation
- single cell
- dna damage
- binding protein
- dendritic cells
- minimally invasive
- cell therapy
- copy number
- stem cells
- oxidative stress
- immune response
- mesenchymal stem cells