Presence of koilocytosis in low-grade smears of high-risk HPV-positive women is a negative predictor for cervical intraepithelial neoplasia grade 3 or more.

Albert G SiebersH van der LindenJ E M VedderR L M BekkersW L G MelchersJ Bulten

Published in: Cytopathology : official journal of the British Society for Clinical Cytology (2018)

The presence of koilocytosis is a negative predictor of CIN3+. The risk of hrHPV-positive ASC-US with koilocytosis is in the same range as hrHPV-positive/cytology negative cases and in a setting of primary hrHPV screening these cases could be followed conservatively by repeat cytology. The results should be confirmed by the first data from the Dutch HPV-based screening programme.

Keyphrases

high grade
low grade
polycystic ovary syndrome
electronic health record
study protocol
randomized controlled trial
type diabetes
metabolic syndrome
machine learning
skeletal muscle
pregnancy outcomes
insulin resistance