Bcl-xL Enforces a Slow-Cycling State Necessary for Survival in the Nutrient-Deprived Microenvironment of Pancreatic Cancer.
Yogev SelaJinyang LiShivahamy MaheswaranRobert NorgardSalina YuanMaimon HubbiMiriam DoepnerJimmy P XuElaine S HoClementina A MesarosColin SheehanGrace CroleyAlexander MuirIan A BlairOphir ShalemChi Van DangBen Z StangerPublished in: Cancer research (2022)
The majority of pancreatic cancer cells inhabit nutrient- and oxygen-poor tumor regions and require Bcl-xL for their survival, providing a compelling antitumor metabolic strategy.
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