Molecular Determinants of Neutrophil Extracellular Vesicles That Drive Cartilage Regeneration in Inflammatory Arthritis.

Bethan L ThomasTrinidad Montero-MelendezSilvia OggeroMagdalena K KanevaDavid ChambersAndreia L PintoAlessandra NervianiDavide LucchesiShani Austin-WilliamsMohammed T HussainCostantino PitzalisBenjamin AllenMarzia MalcangioFrancesco Dell'AccioLucy Victoria NorlingMauro Perretti

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2024)

Neutrophils from patients with RA yielded EVs with composition, efficacy, and miR-455-3p content similar to those of healthy volunteers, suggesting that neutrophil EVs could be developed as an autologous treatment to protect and repair joint tissue of patients affected by inflammatory arthritides.

Keyphrases

end stage renal disease
rheumatoid arthritis
ejection fraction
stem cells
oxidative stress
newly diagnosed
chronic kidney disease
bone marrow
peritoneal dialysis
prognostic factors
patient reported outcomes
mesenchymal stem cells
ankylosing spondylitis
extracellular matrix
interstitial lung disease