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Assessing methotrexate intolerance and its prevalence in rheumatoid arthritis: Development and validation of the MISA questionnaire.

Deeksha VijaykumarArghya ChattopadhyaySiddharth JainVenkatesh PaiJaswinder KaurGodasi Srsnk NaiduAman SharmaShefali Khanna SharmaSanjay Jain
Published in: International journal of rheumatic diseases (2021)
The newly developed MISA questionnaire and score had good predictive ability to diagnose MTX intolerance. Intolerance to MTX was common, being found in one-third of RA patients. Patients with intolerance were twice more likely to discontinue MTX at 1 year.
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