Duodenal Anaerobutyricum soehngenii infusion stimulates GLP-1 production, ameliorates glycaemic control and beneficially shapes the duodenal transcriptome in metabolic syndrome subjects: a randomised double-blind placebo-controlled cross-over study.
Annefleur KoopenJulia WitjesKoen WortelboerSoumia MajaitAndrei ProdanEvgeni LevinHilde HerremaMaaike WinkelmeijerSteven AalvinkJacques J G H M BergmanStephan HavikBolette HartmannHan LevelsPer-Olof BerghJamie van SonManon BalversDiogo Mendes BastosErik StroesAlbert K GroenMarcus HenricssonEllis Marleen KemperJens HolstChristopher M StrauchStanley L HazenFredrik BäckhedWillem Meindert de VosMax NieuwdorpElena RampanelliPublished in: Gut (2021)
NTR-NL6630.
Keyphrases
- placebo controlled
- double blind
- metabolic syndrome
- clinical trial
- study protocol
- phase iii
- phase ii
- phase ii study
- type diabetes
- gene expression
- open label
- low dose
- randomized controlled trial
- genome wide
- insulin resistance
- adipose tissue
- single cell
- cardiovascular risk factors
- dna methylation
- rna seq
- radiation therapy