Potential Relationship between Clinical Significance and Serum Exosomal miRNAs in Patients with Multiple Myeloma.
Zhi-Yao ZhangYan-Chen LiChuan-Ying GengHui-Juan WangWen-Ming ChenPublished in: BioMed research international (2019)
This study evaluated the potential relationship between exosomal miRNAs and clinical symptoms in patients with multiple myeloma (MM). Forty-eight newly diagnosed myeloma patients and sixteen normal donors were enrolled in the study. The results showed that the relative expression levels of let-7c-5p, let-7d-5p, miR-140-3p, miR-185-5p, and miR-425-5p in the exosomes of MM patients were significantly lower than those of healthy controls. Furthermore, there were significant differences in the clinical characteristics of myeloma, such as kidney damage, while the expression levels of the same miRNA in exosomes and serum are not correlated. The expression of exosomal miRNA is related to the expression levels of clinical feature-related factors, such as creatinine, β2-microglobulin, β-CTX, and IL-6 in serum. Establishing this relationship could contribute to understanding the pathogenesis of MM.
Keyphrases
- newly diagnosed
- multiple myeloma
- poor prognosis
- end stage renal disease
- ejection fraction
- chronic kidney disease
- mesenchymal stem cells
- binding protein
- peritoneal dialysis
- machine learning
- long non coding rna
- oxidative stress
- deep learning
- risk assessment
- escherichia coli
- depressive symptoms
- physical activity
- bone marrow
- klebsiella pneumoniae
- human health
- patient reported outcomes