Th17 Cells Secrete TWEAK to Trigger Epithelial-Mesenchymal Transition and Promote Colorectal Cancer Liver Metastasis.

Xin Liu Xin Wang Qingxia Yang Li Luo Ziqin Liu Xiaoxue Ren Kai Lei Shangru Li Zonglin Xie Gaomin Zheng Yifan Zhang Yijie Hao Qianying Zhou Yingdong Hou Fei Fang Wu Song Ji Cui Jinping Ma Wenxuan Xie Shun-Li Shen Ce Tang Sui Peng Jun Yu Ming Kuang Xinming Song Fang Wang Lixia Xu

Published in: Cancer research (2024)

TWEAK secreted by Th17 cells promotes EMT by binding to Fn14 on colorectal cancer cells, suggesting that blocking the TWEAK-Fn14 interaction may be a promising therapeutic approach to inhibit liver metastasis.

Keyphrases

epithelial mesenchymal transition
induced apoptosis
cell cycle arrest
signaling pathway
endoplasmic reticulum stress
oxidative stress
cell death