Uncoupled biological and chronological aging of neutrophils in cancer promotes tumor progression.

Laura A MittmannFlorian HaringJohanna B SchaubächerRoman HennelBojan SmiljanovGabriele ZuchtriegelMartin CanisOlivier GiresFritz KrombachLesca HoldtSven BrandauThomas VoglKirsten LauberBernd UhlChristoph A Reichel

Published in: Journal for immunotherapy of cancer (2022)

Our data uncover a self-sustaining mechanism of malignant neoplasms in fostering protumorigenic phenotypic and functional changes in circulating neutrophils. Interference with this aberrant process might therefore provide a novel, already pharmacologically targetable strategy for cancer immunotherapy.

Keyphrases

electronic health record
papillary thyroid
poor prognosis
squamous cell
lymph node metastasis
squamous cell carcinoma
childhood cancer
young adults
machine learning
big data