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IL21 inhibits miR-361-5p to promote MAP3K9 and further aggravate the progression of shoulder arthritis.

Kangning HaoPengchao LinJing LiJie HuJiangyong WangFei Li
Published in: Aging (2024)
IL21 upregulation and miR-361-5p downregulation characterize shoulder arthritis, resulting in MAP3K9 overexpression. This chain of molecular events boosts MMP expression in chondrocytes and exacerbates the condition's progression.
Keyphrases
  • cell proliferation
  • poor prognosis
  • rheumatoid arthritis
  • signaling pathway
  • rotator cuff
  • high density
  • long non coding rna
  • transcription factor
  • binding protein
  • cell migration
  • single molecule