IL21 inhibits miR-361-5p to promote MAP3K9 and further aggravate the progression of shoulder arthritis.
Kangning HaoPengchao LinJing LiJie HuJiangyong WangFei Li
Published in: Aging (2024)
IL21 upregulation and miR-361-5p downregulation characterize shoulder arthritis, resulting in MAP3K9 overexpression. This chain of molecular events boosts MMP expression in chondrocytes and exacerbates the condition's progression.