Prognostic significance of cell cycle-associated proteins p16, pRB, cyclin D1 and p53 in resected oropharyngeal carcinoma.

Michaela PlathMartina A BroglieDiana FörbsSandro J StoeckliWolfram Jochum

Published in: Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale (2018)

High p16INK4a expression is a reliable marker for survival prognostication in surgically treated OPSCC patients. Protein signatures including the pRB, cyclin D1 and p53 proteins do not further increase the prognostic performance of p16INK4a as a single marker.

Keyphrases

cell cycle
cell proliferation
end stage renal disease
newly diagnosed
prognostic factors
ejection fraction
poor prognosis
chronic kidney disease
peritoneal dialysis
lymph node
binding protein
gene expression
amino acid
dna methylation