Testosterone is sequestered in dysfunctional adipose tissue, modifying androgen-responsive genes.

Andrea Di NisioIva SabovicLuca De ToniMaria Santa RoccaStefano Dall'AcquaBruno AzzenaMaurizio De Rocco PonceCarlo Foresta

Published in: International journal of obesity (2005) (2020)

These results suggest an altered response of dysfunctional fat cells to testosterone stimulation, which normally favors lipolysis and induces an anti-adipogenic effect. The considerable reduction of lipolytic T release after adrenergic stimulation in obese SAT contributes to AT dysfunction, in a feedforward loop further reducing T levels in obese hypogonadal males.

Keyphrases

adipose tissue
replacement therapy
insulin resistance
induced apoptosis
high fat diet
smoking cessation
cell cycle arrest
oxidative stress
genome wide
cancer therapy
weight loss
cell death
endoplasmic reticulum stress
signaling pathway
gene expression
skeletal muscle
drug delivery
obese patients
fatty acid