Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion and Resistance to Immune-Checkpoint Blockade.
Wei WangTaja LozarAthena E GolfinosDenis LeeEllery GronskiElla Ward-ShawMitchell HayesJustine Y BruceRandall J KimpleRong HuPaul M HarariJin XuAysenur KeskePaul M SondelMegan Burke FitzpatrickHuy Q DinhPaul F LambertPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
We demonstrate that K17 expression in HNSCC contributes to immune evasion and resistance to ICB treatment by broadly altering immune landscapes of tumors.
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