Adjunctive antidepressant treatment among 763 outpatients with bipolar disorder: Findings from the Bipolar CHOICE and LiTMUS trials.
Ole Köhler-ForsbergLouisa G SylviaVicki FungLindsay OverhageMichael ThaseJoseph R CalabreseThilo DeckersbachMauricio TohenCharles L BowdenMelvin McInnisJames H KocsisEdward S FriedmanTerence A KetterSusan L McElroyRichard C SheltonMichael Joshua OstacherDan V IosifescuAndrew A NierenbergPublished in: Depression and anxiety (2020)
In this large cohort of outpatients with bipolar disorder, clinically indicated and guideline-based adjunctive antidepressant treatment was not associated with lower depressive symptoms or higher mania symptoms. The treatment-by-indication confounding due to the nonrandomized design of the trials complicates causal interpretations, but no analyses indicated better treatment effects of adjunctive antidepressants.