Polymorphism rs11200638 enhanced HtrA1 responsiveness and expression are associated with age-related macular degeneration.

Fen HeXiaohong LiSuping CaiLan LuTong ZhangMing YangNing FanXizhen WangXuyang Liu

Published in: Eye (London, England) (2021)

Risk haplotype A at rs11200638 significantly increased the responsiveness of HtrA1 promoter to inflammation and subsequently enhanced HtrA1 expression. HtrA1 overexpression induced ARPE-19 apoptosis and growth inhibition, relevant to pathogenesis of AMD.

Keyphrases

age related macular degeneration
poor prognosis
oxidative stress
transcription factor
dna methylation
diabetic rats
binding protein
gene expression
high glucose
cell death
cell cycle arrest
drug induced
pi k akt