Tuberculosis-Learning the Impact of Nutrition (TB LION): protocol for an interventional study to decrease TB risk in household contacts.
Chelsie CintronPrakash Babu NarasimhanLindsey LocksSenbagavalli BabuPranay SinhaNonika RajkumariVaishnavi KaipilyawarAnurag BhargavaKimberly MaloomianPadma ChandrasekaranSheetal VermaNoyal JosephW Evan JohnsonChristine WankeC Robert HorsburghJerrold J EllnerSonali SarkarPadmini SalgameSubitha LakshminarayananNatasha S HochbergPublished in: BMC infectious diseases (2021)
This study will help determine whether undernutrition and parasite infection are associated with gene signatures that predict risk of TB and whether providing nutritional supplementation and/or treating parasitic infections improves immune response towards this infection. This study transcends individual level care and presents the opportunity to benefit the population at large by analyzing factors that affect disease progression potentially reducing the overall burden of people who progress to TB disease. Trial registration ClinicalTrials.gov; NCT03598842; Registered on July 26, 2018; https://clinicaltrials.gov/ct2/show/NCT03598842.
Keyphrases
- mycobacterium tuberculosis
- immune response
- healthcare
- computed tomography
- randomized controlled trial
- genome wide
- dna methylation
- magnetic resonance imaging
- gene expression
- human immunodeficiency virus
- inflammatory response
- hiv aids
- emergency department
- risk factors
- study protocol
- hepatitis c virus
- pain management
- dendritic cells
- physical activity
- open label
- phase iii
- antiretroviral therapy
- dual energy
- adverse drug
- double blind